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soy isoflavones
How Soy Isoflavones Help Prevent Prostate Cancer
Soy isoflavones, such as genistein and
daidzein, are found naturally in soy beans and soy products. They
are antioxidants, but also exhibit similar affects to estrogen in
the human body. In recent years, soy isoflavones have gained much
attention because of their possible protective effects against
prostate cancer. This attention is mainly due to a very low
incidence of prostate cancer in Asian males, whose diets are very
high in soy.
Studies done on isoflavones, in vitro, confirm that these bioactive compounds, specifically genistein and daidzein, have protective affects against prostate cancer cell development. Nevertheless, further studies in humans have not proven as definitive. Most studies on soy isoflavones have been done in Chinese and Japanese men, making it very difficult to translate these results to higher risk populations. In these studies, the men have already been consuming diets very high in soy and therefore it is difficult to asses the benefits that may be seen in other populations.29,30 Still, many of these studies agree that consumption of soy isoflavones does decrease the risk of prostate cancer.
In a study done on native Japanese subjects, men who consumed greater than 32.8 mg/day of genistein showed a 29% decrease in risk of prostate cancer compared with men who consumed less than 13.2 mg/day. In the same study decreases in risks occurred with the consumption of different intakes of daidzein and soy based products, however the results were not significant. Other studies that have focused mainly on the effects of soy foods rather than the consumption of specific isoflavones have shown mixed results.
Furthermore, researchers question the effects of soy isoflavones at different stages of cancer. Various results have been seen in both human and animal studies. For that reason, more research is required to identify when soy isoflavone consumption is the most beneficial. Nevertheless, it is clear that the consumption of soy isoflavones in the form of soy-based products can help to reduce the risks of prostate cancer.
More information about about the role of nutrition in the prevention of prostate cancer can be found in the manual, Nutritional Prevention of Prostate Cancer available at http://www.PreventProstateCancer.com, including an introduction to different foods and food constituents that have been proven to reduce or increase the risks of prostate cancer, and other information designed to aid men in improving their diets so that they can decrease their risks of developing prostate cancer.
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Studies done on isoflavones, in vitro, confirm that these bioactive compounds, specifically genistein and daidzein, have protective affects against prostate cancer cell development. Nevertheless, further studies in humans have not proven as definitive. Most studies on soy isoflavones have been done in Chinese and Japanese men, making it very difficult to translate these results to higher risk populations. In these studies, the men have already been consuming diets very high in soy and therefore it is difficult to asses the benefits that may be seen in other populations.29,30 Still, many of these studies agree that consumption of soy isoflavones does decrease the risk of prostate cancer.
In a study done on native Japanese subjects, men who consumed greater than 32.8 mg/day of genistein showed a 29% decrease in risk of prostate cancer compared with men who consumed less than 13.2 mg/day. In the same study decreases in risks occurred with the consumption of different intakes of daidzein and soy based products, however the results were not significant. Other studies that have focused mainly on the effects of soy foods rather than the consumption of specific isoflavones have shown mixed results.
Furthermore, researchers question the effects of soy isoflavones at different stages of cancer. Various results have been seen in both human and animal studies. For that reason, more research is required to identify when soy isoflavone consumption is the most beneficial. Nevertheless, it is clear that the consumption of soy isoflavones in the form of soy-based products can help to reduce the risks of prostate cancer.
More information about about the role of nutrition in the prevention of prostate cancer can be found in the manual, Nutritional Prevention of Prostate Cancer available at http://www.PreventProstateCancer.com, including an introduction to different foods and food constituents that have been proven to reduce or increase the risks of prostate cancer, and other information designed to aid men in improving their diets so that they can decrease their risks of developing prostate cancer.